Synthesized peptide derived from human pS2 AA range: 25-84

The antibody can specifically recognize human pS2 protein.

TFF1 BCEI PS2

pS2

Trefoil factor 1 ;
Breast cancer estrogen-inducible protein ;
PNR-2 ;
Polypeptide P1.A ;
hP1.A ;
Protein pS2 ;

Members of the trefoil family are characterized by having at least one copy of the trefoil motif , a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined , but they may protect the mucosa from insults , stabilize the mucus layer , and affect healing of the epithelium. This gene , which is expressed in the gastric mucosa , has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq , Jul 2008] ,

Disease:Expressed in a number of carcinomas including breast (50%) , pancreas (70-75%) , stomach (50-55%) , and large bowel (58%) . ,Function:Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. ,similarity:Contains 1 P-type (trefoil) domain. ,subunit:Heterodimer with GKN2; disulfide linked. ,tissue specificity:Found in stomach , with highest levels in the upper gastric mucosal cells (at protein level) . Detected in goblet cells of the small and large intestine and rectum , small submucosal glands in the esophagus , mucous acini of the sublingual gland , submucosal glands of the trachea , and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level) . Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina , and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level) . Detected in urine (at protein level) . Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract , but lower expression found in gastric cancer (at protein level) . ,

Cytoplasmic

>>Estrogen signaling pathway