Catalog: IHCM6832
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100mL
$2,960.00
1 week
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10mL
$356.00
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3mL
$156.00
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Main Information
Target
CD20
Host Species
Mouse
Conjugate/Modification
Unmodified
Detailed Information
Specificity
The antibody can specifically recognize human CD20 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
2°C to 8°C/1 year,Ship by ice bag
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT065
Isotype
IgG1, Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human CD20 AA range: 200-297
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Specificity:
The antibody can specifically recognize human CD20 protein.
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Gene Name:
MS4A1 CD20
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Protein Name:
CD20
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Other Name:
B-lymphocyte antigen CD20 ;
B-lymphocyte surface antigen B1 ;
Bp35 ;
Leukocyte surface antigen Leu-16 ;
Membrane-spanning 4-domains subfamily A member 1 ;
CD antigen CD20 ;
B-lymphocyte surface antigen B1 ;
Bp35 ;
Leukocyte surface antigen Leu-16 ;
Membrane-spanning 4-domains subfamily A member 1 ;
CD antigen CD20 ;
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Background:
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12 , among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq , Jul 2008] ,
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Function:
Caution:Epitope 1 , mapped in PubMed:16785532 , is predicted to be buried in the membrane. Its accessibility to the extracellular space , and thus to antibody recognition , is not explained. ,Function:This protein may be involved in the regulation of B-cell activation and proliferation. ,online information:CD20 entry ,pharmaceutical:Monoclonal antibodies (mAb) against CD20 are used to treat B-cell non-Hodgkin's lymphoma (NHL) . These antibodies include Rituximab (Mabthera) , Britumomab (Zevalin) and Tositumomab (Bexxar) . CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively , mAb can mediate complement-dependent cytotoxicity. ,PTM:Phosphorylated. Might be functionally regulated by protein kinase (s) . ,similarity:Belongs to the MS4A family. ,tissue specificity:Expressed on B-cells. ,
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Cellular Localization:
Membranous
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Tissue Expression:
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Research Areas:
>>Hematopoietic cell lineage
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: IHCM6832
Size
Price
Status
Qty.
100mL
$2,960.00
1 week
0
10mL
$356.00
1 week
0
3mL
$156.00
1 week
0
Add to cart
Collected
Collect
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