Catalog: IHCM6546
Size
Price
Status
Qty.
100mL
$2,960.00
1 week
0
10mL
$356.00
1 week
0
3mL
$156.00
1 week
0
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Collected
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Main Information
Target
Sox-9
Host Species
Mouse
Conjugate/Modification
Unmodified
Detailed Information
Specificity
The antibody can specifically recognize human SOX9 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
2°C to 8°C/1 year,Ship by ice bag
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT-SOX9
Isotype
IgG2b, Kappa
Related Products
Primary Antibodies
SOX9 (ABT-SOX9) Mouse mAb (Ready to Use)
YM6546R
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Primary Antibodies
SOX9 Rabbit pAb
YT4371
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Primary Antibodies
SOX9 (Phospho Ser181) Rabbit pAb
YP0895
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Primary Antibodies
SOX9 (ABT-SOX9) Mouse mAb
YM6546
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ELISA Kits
Total SOX9 Cell-Based Colorimetric ELISA Kit
KA4286C
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ELISA Kits
SOX9 (Phospho Ser181) Cell-Based Colorimetric ELISA Kit
KA1336C
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human SOX9 AA range: 1-100
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Specificity:
The antibody can specifically recognize human SOX9 protein.
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Gene Name:
SOX9
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Protein Name:
Transcription factor SOX-9
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Background:
SRY-box 9 (SOX9) Homo sapiens The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and , with steroidogenic factor 1 , regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia , frequently with sex reversal. [provided by RefSeq , Jul 2008] ,
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Function:
Disease:Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare , often lethal , dominantly inherited , congenital osteochondrodysplasia , associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones , unusually small scapulae , deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate , micrognatia , flat face and hypertelorism are common. Various defects of the ear are often evident , affecting the cochlea , malleus incus , stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage. ,Function:Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. ,similarity:Contains 1 HMG box DNA-binding domain. ,
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Cellular Localization:
Nuclear
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Tissue Expression:
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Research Areas:
>>cAMP signaling pathway
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Signaling Pathway
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Catalog: IHCM6546
Size
Price
Status
Qty.
100mL
$2,960.00
1 week
0
10mL
$356.00
1 week
0
3mL
$156.00
1 week
0
Add to cart
Collected
Collect
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