Catalog: IHCM6183
Size
Price
Status
Qty.
100mL
$2,960.00
1 week
0
10mL
$356.00
1 week
0
3mL
$156.00
1 week
0
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Collected
Collect
Main Information
Target
Claudin 18
Host Species
Mouse
Conjugate/Modification
Unmodified
Detailed Information
Specificity
The antibody can specifically recognize both human Claudin 18.1 and Claudin 18.2 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
2°C to 8°C/1 year,Ship by ice bag
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT158
Isotype
IgG1, Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human Claudin 18 AA range: 150-261
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Specificity:
The antibody can specifically recognize both human Claudin 18.1 and Claudin 18.2 protein.
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Gene Name:
CLDN18 UNQ778/PRO1572
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Protein Name:
Claudin 18
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Other Name:
Claudin-18
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Background:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets , and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq , Jun 2010] ,
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Function:
Function:Plays a major role in tight junction-specific obliteration of the intercellular space , through calcium-independent cell-adhesion activity. ,similarity:Belongs to the claudin family. ,tissue specificity:Concentrated at the cell-cell borders of epithelial cells. ,
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Cellular Localization:
Membranous
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Research Areas:
>>Cell adhesion molecules ;
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: IHCM6183
Size
Price
Status
Qty.
100mL
$2,960.00
1 week
0
10mL
$356.00
1 week
0
3mL
$156.00
1 week
0
Add to cart
Collected
Collect
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