Catalog: YM4266
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
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Collected
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Main Information
Target
GSDMD
Host Species
Mouse
Reactivity
Human, Mouse, Rat,
Applications
WB, IF, ELISA
MW
53kD,31kD (Calculated)
53kD,31kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
This antibody detects endogenous levels of GSDMD protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
53kD,31kD
MW(Observed)
53kD,31kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PTR1398
Isotype
IgG1,kappa
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Antigen&Target Information
Immunogen:
AA range: 1-100
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Specificity:
This antibody detects endogenous levels of GSDMD protein.
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Gene Name:
GSDMD
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Protein Name:
Gasdermin domain-containing protein 1,Gasdermin-D,GSDMD,GSDMD-CT,GSDMD-NT,GSDMD_HUMAN
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Database Link:
| Organism | Gene ID | SwissProt |
|---|---|---|
| Human | P57764; |
Function:
Cleavage at Asp-275 by CASP1 (mature and uncleaved precursor forms), CASP4, CASP5 or CASP8 relieves autoinhibition and is sufficient to initiate pyroptosis (PubMed:26375003, PubMed:29898893, PubMed:32109412). Cleavage by CASP1 and CASP4 is not strictly dependent on the consensus cleavage site on GSDMD but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Cleavage by CASP8 takes place following inactivation of MAP3K7/TAK1 by Yersinia toxin YopJ (By similarity). Cleavage at Asp-87 by CASP3 or CAPS7 inactivates the ability to mediate pyroptosis (PubMed:28392147, PubMed:28045099).
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Cellular Localization:
Cytoplasm
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Tissue Expression:
Expressed in the suprabasal cells of esophagus, as well as in the isthmus/neck, pit, and gland of the stomach, suggesting preferential expression in differentiating cells.
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Research Areas:
>>Neutrophil extracellular trap formation ;
>>NOD-like receptor signaling pathway ;
>>Salmonella infection
>>NOD-like receptor signaling pathway ;
>>Salmonella infection
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Reference Citation({{totalcount}})
Catalog: YM4266
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
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