Synthesized peptide derived from human protein . at AA range: 220-300

CCNT1 Polyclonal Antibody detects endogenous levels of protein.

CCNT1

Cyclin-T1 (CycT1) (Cyclin-T)

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9 , and is a major subunit of positive transcription elongation factor b (p-TEFb) . In humans , there are multiple forms of positive transcription elongation factor b , which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein , and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcrip

Function:Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex , also called positive transcription elongation factor B (P-TEFb) , which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) . In case of HIV or SIV infections , binds to the transactivation domain of the viral nuclear transcriptional activator , Tat , thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA) . Serves as an essential cofactor for Tat , by promoting RNA Pol II activation , allowing transcription of viral genes. ,miscellaneous:Interaction between Tat and cyclin-T1 requires zinc. ,similarity:Belongs to the cyclin family. Cyclin C subfamily. ,subunit:Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Interacts with the transactivation region of HIV-1 , HIV-2 and SIV Tat. Component of a complex which is at least composed of HTATSF1/Tat-SF1 , P-TEFb complex , RNA pol II , SUPT5H , and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) , HEXIM1 , HEXIM2 , BCDIN3 , SART3 proteins and 7SK and U6 snRNAs. Interacts with MDFIC. ,tissue specificity:Ubiquitously expressed. ,

Nucleus .

>>Viral life cycle - HIV-1 ;
>>Transcriptional misregulation in cancer