Amino acid: 9-138, with his-MBP tag.

CCND1

Cyclin D1 protein

G1/S-specific cyclin-D1 ;
B-cell lymphoma 1 protein ;
BCL-1 ;
BCL-1 oncogene ;
PRAD1 oncogene ;

disease:A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.,disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t(11;14)(q13;q32) with the IgH locus.,disease:A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.,function:Essential for the control of the cell cycle at the G1/S (start) transition.,online information:The Singapore human mutation and polymorphism database,PTM:Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest.,PTM:Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin D subfamily.,subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.,

cell cycle checkpoint, DNA damage checkpoint, regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle, mitotic cell cycle, re-entry into mitotic cell cycle, liver development, regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, reproductive developmental process,protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, response to DNA damage stimulus, ER-nuclear signaling pathway, response to unfolded protein, cell cycle, mitotic cell cycle checkpoint,cell surface receptor linked signal transduction, intracellular signaling cascade, regulation of mitotic cell cycle, sex differentiation, response to nutrient, positive regulation of cell proliferation, gonad development, male gonad development, response to radiation, response to UV, response to light stimulus, response to abiotic stimulus,response to endogenous stimulus, response to hormone stimulus, negative regulation of signal transduction,response to extracellular stimulus, response to organic substance, response to inorganic substance, response to metal ion, response to iron ion, response to X-ray, response to ionizing radiation, response to organic nitrogen,positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, negative regulation of cell communication, response to organic cyclic substance, Wnt receptor signaling pathway,phosphorylation, regulation of phosphate metabolic process, cell cycle process, cell cycle phase, regulation of Wnt receptor signaling pathway, negative regulation of Wnt receptor signaling pathway, regulation of epithelial cell differentiation, negative regulation of epithelial cell differentiation, endoplasmic reticulum unfolded protein response,regeneration, organ regeneration, regulation of protein modification process, positive regulation of protein modification process, DNA integrity checkpoint, G1 DNA damage checkpoint, G1/S transition checkpoint, response to nutrient levels, response to corticosteroid stimulus, response to magnesium ion, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, response to vitamin E, response to vitamin, Leydig cell differentiation, cellular response to stress, positive regulation of kinase activity, cellular response to unfolded protein, response to endoplasmic reticulum stress, cellular response to DNA damage stimulus, regulation of cell proliferation, regulation of phosphorylation, positive regulation of phosphorylation, response to drug, DNA damage response, signal transduction, positive regulation of catalytic activity, regulation of kinase activity, response to estrogen stimulus, positive regulation of molecular function, development of primary sexual characteristics, fat cell differentiation, response to ethanol, negative regulation of cell differentiation, positive regulation of cyclin-dependent protein kinase activity, positive regulation of cell cycle, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of phosphate metabolic process, development of primary male sexual characteristics, male sex differentiation, response to steroid hormone stimulus, reproductive structure development,reproductive cellular process, regulation of phosphorus metabolic process, positive regulation of protein metabolic process, cell division, interphase, interphase of mitotic cell cycle, regulation of transferase activity, positive regulation of transferase activity, response to glucocorticoid stimulus, response to mineralocorticoid stimulus, response to corticosterone stimulus, response to calcium ion, regulation of cell cycle, response to protein stimulus, Wnt receptor signaling pathway through beta-catenin, response to UV-A,

Nucleus . Cytoplasm . Nucleus membrane . Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. .