Catalog: YT4636
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
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Main Information
Target
TGR5
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA, IHC
MW
35kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
TGR5 Polyclonal Antibody detects endogenous levels of TGR5 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
35kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human GPBAR. AA range:11-60
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Specificity:
TGR5 Polyclonal Antibody detects endogenous levels of TGR5 protein.
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Gene Name:
GPBAR1
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Protein Name:
G-protein coupled bile acid receptor 1
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Other Name:
GPBAR1 ;
TGR5 ;
G-protein coupled bile acid receptor 1 ;
G-protein coupled receptor GPCR19 ;
hGPCR19 ;
Membrane-type receptor for bile acids ;
M-BAR ;
hBG37 ;
BG37
TGR5 ;
G-protein coupled bile acid receptor 1 ;
G-protein coupled receptor GPCR19 ;
hGPCR19 ;
Membrane-type receptor for bile acids ;
M-BAR ;
hBG37 ;
BG37
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Background:
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
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Function:
Function:Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.,
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Cellular Localization:
Cell membrane ; Multi-pass membrane protein .
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Reference Citation({{totalcount}})
Catalog: YT4636
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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