MAP3K2 rabbit pAb
- Catalog No.:YT7790
- Applications:WB;ELISA
- Reactivity:Human;Rat;Mouse;
- Target:
- MAP3K2
- Fields:
- >>MAPK signaling pathway;>>Gap junction;>>GnRH signaling pathway
- Gene Name:
- MAP3K2 MAPKKK2 MEKK2
- Protein Name:
- MAP3K2
- Human Gene Id:
- 10746
- Human Swiss Prot No:
- Q9Y2U5
- Mouse Swiss Prot No:
- Q61083
- Immunogen:
- Synthesized peptide derived from human MAP3K2 AA range: 220-300
- Specificity:
- This antibody detects endogenous levels of Human MAP3K2
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:1000-2000 ELISA 1:5000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25;MAPK/ERK kinase kinase 2;MEK kinase 2;MEKK 2)
- Molecular Weight(Da):
- 68kD
- Background:
- The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008],
- Function:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-524.,function:Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Upon EGF stimulation, translocates into the nucleus.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,
- Subcellular Location:
- Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus.
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