MAP3K2 rabbit pAb

  • Catalog No.:YT7790
  • Applications:WB;ELISA
  • Reactivity:Human;Rat;Mouse;
    • Target:
    • MAP3K2
    • Fields:
    • >>MAPK signaling pathway;>>Gap junction;>>GnRH signaling pathway
    • Gene Name:
    • MAP3K2 MAPKKK2 MEKK2
    • Protein Name:
    • MAP3K2
    • Human Swiss Prot No:
    • Q9Y2U5
    • Mouse Swiss Prot No:
    • Q61083
    • Immunogen:
    • Synthesized peptide derived from human MAP3K2 AA range: 220-300
    • Specificity:
    • This antibody detects endogenous levels of Human MAP3K2
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:1000-2000 ELISA 1:5000-20000
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name:
    • Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25;MAPK/ERK kinase kinase 2;MEK kinase 2;MEKK 2)
    • Molecular Weight(Da):
    • 68kD
    • Background:
    • The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008],
    • Function:
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-524.,function:Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Upon EGF stimulation, translocates into the nucleus.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,
    • Subcellular Location:
    • Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus.