• Target：
• Glutaredoxin-1

• Gene Name：
• GLRX GRX

• Protein Name：
• Glutaredoxin-1

• Human Gene Id：
• 2745

• Human Swiss Prot No：
• P35754

• Immunogen：
• Synthesized peptide derived from human Glutaredoxin-1 AA range: 8-58

• Specificity：
• This antibody detects endogenous levels of human Glutaredoxin-1

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Glutaredoxin-1 (Thioltransferase-1;TTase-1)

• Molecular Weight(Da)：
• 12kD

• Background：
• This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011],

• Function：
• function:Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.,similarity:Belongs to the glutaredoxin family.,similarity:Contains 1 glutaredoxin domain.,

• Subcellular Location：
• Cytoplasm.

• Expression：
• Blood,Brain,Lens,Liver,Skin,Spleen,Urinary bladder,

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