Jagged1 Polyclonal Antibody

  • Catalog No.:YT6212
  • Applications:IHC-p,WB
  • Reactivity:Human, Mouse, Rat
  • Description
  • Gene Name:
  • JAG1 JAGL1
  • Protein Name:
  • Jagged1
  • Human Gene Id:
  • 182
  • Human Swiss Prot No:
  • P78504
  • Immunogen:
  • Synthesized peptide derived from human Jagged1
  • Specificity:
  • This antibody detects endogenous levels of human Jagged1
  • Formulation:
  • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source:
  • Rabbit
  • Dilution:
  • IHC-p 1:50-200, WB 1:500-2000
  • Purification:
  • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration:
  • 1 mg/ml
  • Storage Stability:
  • -20°C/1 year
  • Other Name:
  • Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)
  • Observed Band(KD):
  • 133
  • Background:
  • jagged 1(JAG1) Homo sapiens The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008],
  • Function:
  • developmental stage:Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.,disease:Defects in JAG1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.,disease:Defects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM:118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis
  • Subcellular Location:
  • extracellular region,plasma membrane,integral component of plasma membrane,adherens junction,membrane,integral component of membrane,apical plasma membrane,
  • Expression:
  • Bone marrow,Brain,Cervix carcinoma,Placenta,Umbilical vein,Umbilical vein endothelial cell,