Jagged1 Polyclonal Antibody

  • Catalog No.:YT6212
  • Applications:IHC-p,WB
  • Reactivity:Human, Mouse, Rat
  • Description
  • Gene Name:
  • JAG1 JAGL1
  • Protein Name:
  • Jagged1
  • Human Gene Id:
  • 182
  • Human Swiss Prot No:
  • P78504
  • Immunogen:
  • Synthesized peptide derived from human Jagged1
  • Specificity:
  • This antibody detects endogenous levels of human Jagged1
  • Formulation:
  • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source:
  • Rabbit
  • Dilution:
  • IHC-p 1:50-200, WB 1:500-2000
  • Purification:
  • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration:
  • 1 mg/ml
  • Storage Stability:
  • -20°C/1 year
  • Other Name:
  • Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)
  • Observed Band(KD):
  • 133
  • Background:
  • The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
  • Function:
  • angiogenesis, blood vessel development, cell fate determination, vasculature development, morphogenesis of an epithelium, morphogenesis of an epithelial sheet, immune system development, cell surface receptor linked signal transduction, Notch signaling pathway, ectoderm development, sensory organ development, epidermis development,regulation of Notch signaling pathway, epidermal cell differentiation, positive regulation of signal transduction, positive regulation of cell communication, hemopoiesis, neuron differentiation, keratinocyte differentiation, regulation of cell migration, epithelial cell differentiation, regulation of locomotion, regulation of cell proliferation, mechanoreceptor differentiation, auditory receptor cell differentiation, muscle cell differentiation, ear development, cell fate commitment,myoblast differentiation, endothelial cell differentiation, negative regulation