NFATc2 Polyclonal Antibody

    • Catalog No.:YT6023
    • Applications:IHC-p,ELISA
    • Reactivity:Human,Mouse,Rat
      • Gene Name:
      • NFATC2 NFAT1 NFATP
      • Protein Name:
      • Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)
      • Human Gene Id:
      • 4773
      • Human Swiss Prot No:
      • Q13469
      • Mouse Swiss Prot No:
      • Q60591
      • Immunogen:
      • Synthetic peptide from human protein at AA range: 640-700
      • Specificity:
      • The antibody detects endogenous NFATc2
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • IHC-p 1:50-200, ELISA 1:10000-20000
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)
      • Background:
      • nuclear factor of activated T-cells 2(NFATC2) Homo sapiens This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012],
      • Function:
      • alternative products:Additional isoforms seem to exist,domain:Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.,function:Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF.,induction:Inducibly expressed in T-lymphocytes upon activation of the T-cell receptor (TCR) complex. Induced after co-addition of phorbol 12-myristate 13-acetate (PMA) and ionomycin.,PTM:In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full
      • Subcellular Location:
      • nuclear chromatin,nucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane,actin cytoskeleton,intracellular ribonucleoprotein complex,nuclear transcription factor complex,
      • Expression:
      • Pooled,T-cell,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded Human-colon, antibody was diluted at 1:100