IL-1F5 Polyclonal Antibody

    • Catalog No.:YT5720
    • Applications:WB;ELISA
    • Reactivity:Human;Mouse;Rat
      • Target:
      • IL-1F5
      • Fields:
      • >>Cytokine-cytokine receptor interaction
      • Gene Name:
      • IL36RN
      • Protein Name:
      • Interleukin-36 receptor antagonist protein
      • Human Swiss Prot No:
      • Q9UBH0
      • Mouse Swiss Prot No:
      • Q9QYY1
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from the Internal region of human IL36RN. AA range:1-50
      • Specificity:
      • IL-1F5 Polyclonal Antibody detects endogenous levels of IL-1F5 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • IL36RN;FIL1D;IL1F5;IL1HY1;IL1L1;IL1RP3;Interleukin-36 receptor antagonist protein;FIL1 delta;IL-1-related protein 3;IL-1RP3;Interleukin-1 HY1;IL-1HY1;Interleukin-1 delta;IL-1 delta;Interleukin-1 family member 5;IL-1F5;Interleukin-1 receptor antagonist homolog 1;IL-1ra homolog 1;Interleukin-1-like protein 1;IL-1L1
      • Observed Band(KD):
      • 17kD
      • Background:
      • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008],
      • Function:
      • function:Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.,induction:By phorbol ester (PMA) and lipopolysaccharide (LPS) treatment in macrophage cell line.,online information:Interleukin-1 entry,similarity:Belongs to the IL-1 family.,tissue specificity:Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.,
      • Subcellular Location:
      • Cytoplasm . Secreted . The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. .
      • Expression:
      • Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
      • Products Images
      • Western blot analysis of RAT-KIDNEY 293T lysis using IL36RN antibody. Antibody was diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000