• Target：
• Ox40

• Fields：
• >>Cytokine-cytokine receptor interaction

• Gene Name：
• TNFRSF4

• Protein Name：
• Tumor necrosis factor receptor superfamily member 4

• Human Gene Id：
• 7293

• Human Swiss Prot No：
• P43489

• Mouse Swiss Prot No：
• P47741

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human TNFRSF4. AA range:131-180

• Specificity：
• Ox40 Polyclonal Antibody detects endogenous levels of Ox40 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TNFRSF4;TXGP1L;Tumor necrosis factor receptor superfamily member 4;ACT35 antigen;OX40L receptor;TAX transcriptionally-activated glycoprotein 1 receptor;CD134

• Observed Band(KD)：
• 30kD

• Background：
• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008],

• Function：
• function:Receptor for TNFSF4/OX40L/GP34.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Interacts with TRAF2, TRAF3 and TRAF5.,

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Brain,

TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways. Hepatobiliary & Pancreatic Diseases International Yong Wang WB Human hepatocellular cancer (HCC) tissues

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