• Target：
• MyoD

• Fields：
• >>Spinocerebellar ataxia

• Gene Name：
• MYOD1

• Protein Name：
• Myoblast determination protein 1

• Human Gene Id：
• 4654

• Human Swiss Prot No：
• P15172

• Mouse Gene Id：
• 17927

• Mouse Swiss Prot No：
• P10085

• Rat Gene Id：
• 337868

• Rat Swiss Prot No：
• Q02346

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MyoD around the non-acetylation site of Lys99/102. AA range:61-110

• Specificity：
• MyoD Polyclonal Antibody detects endogenous levels of MyoD protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MYOD1;BHLHC1;MYF3;MYOD;Myoblast determination protein 1;Class C basic helix-loop-helix protein 1;bHLHc1;Myogenic factor 3;Myf-3

• Observed Band(KD)：
• 35kD

• Background：
• This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008],

• Function：
• function:Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.,online information:MyoD entry,PTM:Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function.,PTM:Ubiquitinated on the N-terminus; which is required for proteasomal degradation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1.,

• Subcellular Location：
• Nucleus.

• Expression：
• Muscle,Skeletal muscle,

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