SNM1B Polyclonal Antibody
- Catalog No.:YT5064
- Applications:WB;ELISA;IHC
- Reactivity:Human;Rat;Mouse;
- Target:
- SNM1B
- Gene Name:
- DCLRE1B
- Protein Name:
- 5' exonuclease Apollo
- Human Gene Id:
- 64858
- Human Swiss Prot No:
- Q9H816
- Mouse Swiss Prot No:
- Q8C7W7
- Immunogen:
- Synthesized peptide derived from the C-terminal region of human SNM1B.
- Specificity:
- SNM1B Polyclonal Antibody detects endogenous levels of SNM1B protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- DCLRE1B;SNM1B;5' exonuclease Apollo;DNA cross-link repair 1B protein;SNM1 homolog B;SNMIB;hSNM1B
- Observed Band(KD):
- 60kD
- Background:
- DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008],
- Function:
- function:May be required for DNA interstrand cross-link repair.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.,subcellular location:Localizes to discrete foci.,
- Subcellular Location:
- Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.
- Expression:
- Placenta,Retinoblastoma,Teratocarcinoma,
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- Antibody-FAQs
- Products Images
- Western Blot analysis of extracts from K562, Jurkat cells, using SNM1B Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
- Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).