SNM1B Polyclonal Antibody

    • Catalog No.:YT5064
    • Applications:WB;ELISA;IHC
    • Reactivity:Human;Rat;Mouse;
      • Target:
      • SNM1B
      • Gene Name:
      • DCLRE1B
      • Protein Name:
      • 5' exonuclease Apollo
      • Human Swiss Prot No:
      • Q9H816
      • Mouse Swiss Prot No:
      • Q8C7W7
      • Immunogen:
      • Synthesized peptide derived from the C-terminal region of human SNM1B.
      • Specificity:
      • SNM1B Polyclonal Antibody detects endogenous levels of SNM1B protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • DCLRE1B;SNM1B;5' exonuclease Apollo;DNA cross-link repair 1B protein;SNM1 homolog B;SNMIB;hSNM1B
      • Observed Band(KD):
      • 60kD
      • Background:
      • DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008],
      • Function:
      • function:May be required for DNA interstrand cross-link repair.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.,subcellular location:Localizes to discrete foci.,
      • Subcellular Location:
      • Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.
      • Expression:
      • Placenta,Retinoblastoma,Teratocarcinoma,
      • Products Images
      • Western Blot analysis of extracts from K562, Jurkat cells, using SNM1B Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
      • Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).