VAMP-4 Polyclonal Antibody

    • Catalog No.:YT4851
    • Applications:IF;ELISA
    • Reactivity:Human;Mouse
      • Target:
      • VAMP4
      • Fields:
      • >>SNARE interactions in vesicular transport
      • Gene Name:
      • VAMP4
      • Protein Name:
      • Vesicle-associated membrane protein 4
      • Human Gene Id:
      • 8674
      • Human Swiss Prot No:
      • O75379
      • Mouse Swiss Prot No:
      • O70480
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human VAMP4. AA range:1-50
      • Specificity:
      • VAMP-4 Polyclonal Antibody detects endogenous levels of VAMP-4 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • VAMP4;Vesicle-associated membrane protein 4;VAMP-4
      • Molecular Weight(Da):
      • 16kD
      • Background:
      • Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008],
      • Function:
      • function:Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subcellular location:Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.,subunit:Identified in a complex containing STX6, STX13, VAMP4 and VTI1A.,
      • Subcellular Location:
      • Golgi apparatus, trans-Golgi network membrane ; Single-pass type IV membrane protein . Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.
      • Expression:
      • B-cell,Bone marrow,Epithelium,Liver,Urinary bladder,
      • Products Images
      • Immunofluorescence analysis of A549 cells, using VAMP4 Antibody. The picture on the right is blocked with the synthesized peptide.