• Target：
• TSSK 4

• Gene Name：
• TSSK4

• Protein Name：
• Testis-specific serine/threonine-protein kinase 4

• Human Gene Id：
• 283629

• Human Swiss Prot No：
• Q6SA08

• Mouse Gene Id：
• 71099

• Mouse Swiss Prot No：
• Q9D411

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TSSK4. AA range:211-260

• Specificity：
• TSSK 4 Polyclonal Antibody detects endogenous levels of TSSK 4 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TSSK4;C14orf20;STK22E;TSSK5;Testis-specific serine/threonine-protein kinase 4;TSK-4;TSSK-4;Testis-specific kinase 4;Serine/threonine-protein kinase 22E

• Observed Band(KD)：
• 40kD

• Background：
• This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-197, potentially by autophosphorylation.,function:May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling.,PTM:Autophosphorylated (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed only in the testis.,

• Subcellular Location：
• Cytoplasmic vesicle, secretory vesicle, acrosome . Cell projection, cilium, flagellum . In spermatozoa, present in the sperm head and in the flagellum. .

• Expression：
• Expressed only in the testis.

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