Tau Polyclonal Antibody

    • Catalog No.:YT4545
    • Applications:WB,ELISA
    • Reactivity:Human,Mouse,Rat
      • Gene Name:
      • MAPT
      • Protein Name:
      • Microtubule-associated protein tau
      • Human Gene Id:
      • 4137
      • Human Swiss Prot No:
      • P10636
      • Mouse Swiss Prot No:
      • P10637
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human Tau. AA range:521-570
      • Specificity:
      • Tau Polyclonal Antibody detects endogenous levels of Tau protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • MAPT; MAPTL; MTBT1; TAU; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
      • MolecularWeight(Da):
      • 78746
      • Observed Band(KD):
      • 50-85
      • Background:
      • microtubule associated protein tau(MAPT) Homo sapiens This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008],
      • Function:
      • alternative products:Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat,developmental stage:Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) tau is found in both adult and fetal brain.,disease:Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive supranuclear palsy, and Parkinson disease.,disease:Defects in MAPT are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17) [MIM:600274, 172700]; also called frontotemporal dementia (FTD) or historically termed Pick complex. This form
      • Subcellular Location:
      • cytoplasm,cytosol,microtubule,microtubule associated complex,plasma membrane,axoneme,postsynaptic density,axon,dendrite,growth cone,nuclear periphery,cytoplasmic ribonucleoprotein granule,cell body,
      • Expression:
      • Brain,Brain cortex,Epithelium,Fetal brain,Fetal brain cortex,
      • Products Images
      • Western Blot analysis of various cells using Tau Polyclonal Antibody diluted at 1:1000
      • Western blot analysis of lysates from MDA-MB-435 cells, using Tau Antibody. The lane on the right is blocked with the synthesized peptide.