Rsk-3 Polyclonal Antibody

    • Catalog No.:YT4184
    • Applications:IHC-p,IF(paraffin section),WB,ELISA
    • Reactivity:Human,Mouse
      • Gene Name:
      • RPS6KA2
      • Protein Name:
      • Ribosomal protein S6 kinase alpha-2
      • Human Gene Id:
      • 6196
      • Human Swiss Prot No:
      • Q15349
      • Mouse Swiss Prot No:
      • Q9WUT3
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human S6K-alpha2. AA range:241-290
      • Specificity:
      • Rsk-3 Polyclonal Antibody detects endogenous levels of Rsk-3 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • IF(paraffin section) 1:50-200 IHC: 1/100 - 1/300.WB:1/500-1/2000 ELISA: 1/20000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • RPS6KA2; MAPKAPK1C; RSK3; Ribosomal protein S6 kinase alpha-2; S6K-alpha-2; 90 kDa ribosomal protein S6 kinase 2; p90-RSK 2; p90RSK2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; Ri
      • MolecularWeight(Da):
      • 83239
      • Background:
      • ribosomal protein S6 kinase A2(RPS6KA2) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016],
      • Function:
      • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-377, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,tissue specificity:Expressed in many tissues. Highest expression in lung and skeletal muscle.,
      • Subcellular Location:
      • nucleus,nucleoplasm,cytoplasm,spindle,cytosol,ribosome,nuclear membrane,
      • Expression:
      • Brain,Muscle,
      • Products Images
      • Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue, using S6K-alpha2 Antibody. The picture on the right is blocked with the synthesized peptide.