• Target：
• Internexin-α

• Gene Name：
• INA

• Protein Name：
• Alpha-internexin

• Human Gene Id：
• 9118

• Human Swiss Prot No：
• Q16352

• Mouse Gene Id：
• 226180

• Mouse Swiss Prot No：
• P46660

• Rat Gene Id：
• 24503

• Rat Swiss Prot No：
• P23565

• Immunogen：
• Synthesized peptide derived from the Internal region of human Internexin-α.

• Specificity：
• Internexin-α Polyclonal Antibody detects endogenous levels of Internexin-α protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• INA;NEF5;Alpha-internexin;Alpha-Inx;66 kDa neurofilament protein;NF-66;Neurofilament-66;Neurofilament 5

• Observed Band(KD)：
• 55kD

• Background：
• Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009],

• Function：
• developmental stage:Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation.,function:Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.,PTM:O-glycosylated.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the intermediate filament family.,tissue specificity:Found predominantly in adult CNS.,

• Subcellular Location：
• extracellular space,nucleoplasm,neurofilament,nuclear membrane,cytoplasmic ribonucleoprotein granule,myelin sheath,intermediate filament cytoskeleton,

• Expression：
• Found predominantly in adult CNS.

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