• Target：
• D4DR

• Fields：
• >>Neuroactive ligand-receptor interaction;>>Dopaminergic synapse

• Gene Name：
• DRD4

• Protein Name：
• D(4) dopamine receptor

• Human Gene Id：
• 1815

• Human Swiss Prot No：
• P21917

• Mouse Gene Id：
• 13491

• Mouse Swiss Prot No：
• P51436

• Rat Gene Id：
• 25432

• Rat Swiss Prot No：
• P30729

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human DRD4. AA range:355-404

• Specificity：
• D4DR Polyclonal Antibody detects endogenous levels of D4DR protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DRD4;D(4) dopamine receptor;D(2C) dopamine receptor;Dopamine D4 receptor

• Observed Band(KD)：
• 48kD

• Background：
• This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008],

• Function：
• function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,polymorphism:The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with CLIC6 (By similarity) and GPRASP1.,

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein .

• Expression：
• Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary.

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