Cytokeratin 19 Polyclonal Antibody

    • Catalog No.:YT1276
    • Applications:WB,IHC-p,ELISA
    • Reactivity:Human,Mouse,Rat
      • Gene Name:
      • KRT19
      • Protein Name:
      • Keratin type I cytoskeletal 19
      • Human Gene Id:
      • 3880
      • Human Swiss Prot No:
      • P08727
      • Mouse Swiss Prot No:
      • P19001
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human Cytokeratin 19. AA range:300-349
      • Specificity:
      • Cytokeratin 19 Polyclonal Antibody detects endogenous levels of Cytokeratin 19 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • KRT19; Keratin; type I cytoskeletal 19; Cytokeratin-19; CK-19; Keratin-19; K19
      • MolecularWeight(Da):
      • 44092/59511/53511
      • Observed Band(KD):
      • 40
      • Background:
      • keratin 19(KRT19) Homo sapiens The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008],
      • Function:
      • developmental stage:Present in hair follicles at all stages of development.,domain:This keratin differs from all other IF proteins in lacking the C-terminal tail domain.,function:Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.,tissue specificity:Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestin
      • Subcellular Location:
      • intermediate filament,plasma membrane,dystrophin-associated glycoprotein complex,Z disc,sarcolemma,costamere,extracellular exosome,cell periphery,terminal web,
      • Expression:
      • Keratinocyte,Lymph node,Mammary gland,Pancreas,Peripheral blood leukocyte,Placenta,
      • Products Images
      • Immunohistochemistry analysis of Cytokeratin?19 antibody in paraffin-embedded human breast carcinoma tissue.
      • Western blot analysis of lysate from K562 cells, using Cytokeratin?19 antibody.