• Target：
• FRS2

• Fields：
• >>Thermogenesis;>>Neurotrophin signaling pathway;>>Proteoglycans in cancer

• Gene Name：
• FRS2

• Protein Name：
• FRS2-α (Tyr196)

• Human Gene Id：
• 10818

• Human Swiss Prot No：
• Q8WU20

• Mouse Gene Id：
• 327826

• Mouse Swiss Prot No：
• Q8C180

• Immunogen：
• Synthesized phosho peptide around human FRS2-α (Tyr196)

• Specificity：
• This antibody detects endogenous levels of Human Mouse FRS2-α (phospho-Tyr196)

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:1000-2000

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)

• Observed Band(KD)：
• 65kD

• Function：
• function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and t

• Subcellular Location：
• Endomembrane system. Cytoplasmic, membrane-bound.

• Expression：
• Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

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