HER2 (Phospho-Tyr1139) Polyclonal Antibody

  • Catalog No.:YP1240
  • Applications:IHC-p,IF(paraffin section),WB
  • Reactivity:Human, Mouse, Rat
    • Gene Name:
    • ERBB2 HER2 MLN19 NEU NGL
    • Protein Name:
    • HER2 (Phospho-Tyr1139)
    • Human Gene Id:
    • 2064
    • Human Swiss Prot No:
    • P04626
    • Immunogen:
    • Synthesized peptide derived from human HER2 (Phospho-Tyr1139)
    • Specificity:
    • This antibody detects endogenous phospho levels of HER2 (Phospho-Tyr1139) at Human:Y1139, Mouse:Y1140, Rat:Y1141
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Rabbit
    • Dilution:
    • IHC-p 1:50-200, WB 1:500-2000
    • Purification:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
    • Observed Band(KD):
    • 180
    • Background:
    • erb-b2 receptor tyrosine kinase 2(ERBB2) Homo sapiens This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d
    • Function:
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in ERBB2 are associated with familial glioma of brain [MIM:137800]; also called glioblastoma multiforme. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas.,disease:Defects in ERBB2 are associated with gastric cancer [MIM:137215]; also known as hereditary familial diffuse gastric cancer (HDGC).,disease:Defects in ERBB2 are associated with lung cancer [MIM:211980]; also called adenocarcinoma of lung.,disease:Defects in ERBB2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of viscera
    • Subcellular Location:
    • nucleus,cytoplasm,plasma membrane,endosome membrane,membrane,integral component of membrane,basolateral plasma membrane,apical plasma membrane,cytoplasmic vesicle,myelin sheath,receptor complex,perinuclear region
    • Expression:
    • Epithelium,Lung,Mammary carcinoma,Placenta,