• Target：
• Actin β

• Fields：
• >>Rap1 signaling pathway;>>Phagosome;>>Apoptosis;>>Hippo signaling pathway;>>Focal adhesion;>>Adherens junction;>>Tight junction;>>Platelet activation;>>Neutrophil extracellular trap formation;>>Leukocyte transendothelial migration;>>Thermogenesis;>>Regulation of actin cytoskeleton;>>Thyroid hormone signaling pathway;>>Oxytocin signaling pathway;>>Gastric acid secretion;>>Amyotrophic lateral sclerosis;>>Bacterial invasion of epithelial cells;>>Vibrio cholerae infection;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Yersinia infection;>>Influenza A;>>Proteoglycans in cancer;>>Hepatocellular carcinoma;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy;>>Viral myocarditis;>>Fluid shear stress and atherosclerosis

• Gene Name：
• ACTB

• Protein Name：
• Actin cytoplasmic 1

• Human Gene Id：
• 60

• Human Swiss Prot No：
• P60709

• Mouse Gene Id：
• 11461

• Mouse Swiss Prot No：
• P60710

• Rat Gene Id：
• 81822

• Rat Swiss Prot No：
• P60711

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:2000-1:20000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ACTB;Actin; cytoplasmic 1;Beta-actin;Actin β;β-Actin;Beta actin;B actin;actin Beta;

• Molecular Weight(Da)：
• 42kD

• Observed Band(KD)：
• 42kD

• Background：
• This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the

• Subcellular Location：
• Cytoplasm

• Expression：
• B-cell lymphoma,Brain,Cajal-Retzius cell,Eye,Fetal brain cortex,Foreskin,Hepatocellular car

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DBA-induced caspase-3-dependent apoptosis occurs through mitochondrial translocation of cyt-c in the rat hippocampus. Molecular BioSystems Mol Biosyst. 2017 Aug;13(9):1863-1873 WB Rat 1:1000 hippocampus

Enhanced effects of salidroside on erectile function and corpora cavernosa autophagy in a cavernous nerve injury rat model. ANDROLOGIA Andrologia. 2021 Jul;53(6):e14044 WB Rat 1 : 1000 Penile

The spinal NR2BR/ERK2 pathway as a target for the central sensitization of collagen-induced arthritis pain. PLoS One 2018 Jul 19 WB Mouse 1:1000 cerebral spinal

Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive Hearing Loss and Retinal Degeneration in C57BL/6J Mice. G3-Genes Genomes Genetics G3-Genes Genom Genet. 2018 Oct;8(10):3221-3230 WB Mouse 1:2000 cochleae tissue

Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice by suppressing activation of NF-κB signal pathway. INTERNATIONAL IMMUNOPHARMACOLOGY 2014 Nov 15 WB Mouse uteri

Crocin induces autophagic apoptosis in hepatocellular carcinoma by inhibiting Akt/mTOR activity. OncoTargets and Therapy Oncotargets Ther. 2018; 11: 2017–2028 WB Human HepG2 cell， HCCLM3 cell

Effects of the combination of As2O3 and AZT on proliferation inhibition and apoptosis induction of hepatoma HepG2 cells following silencing of Egr-1. OncoTargets and Therapy Oncotargets Ther. 2018; 11: 3293–3301 WB Human HepG2 cell

Silver Nanoparticles Induced Oxidative Stress and Mitochondrial Injuries Mediated Autophagy in HC11 Cells Through Akt/AMPK/mTOR Pathway. BIOLOGICAL TRACE ELEMENT RESEARCH Biol Trace Elem Res. 2021 Mar;199(3):1062-1073 WB Human 1 : 1000 HC11 cell

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Aberrant methylation‐induced dysfunction of p16 is associated with osteoblast activation caused by fluoride. ENVIRONMENTAL TOXICOLOGY Environ Toxicol. 2019 Jan;34(1):37-47 WB Human osteoblasts

Collagen External Scaffolds Mitigate Intimal Hyperplasia and Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Graft Model. Biomed Research International Biomed Res Int. 2017;2017:7473437 WB Rabbit 1 : 5000 VSMCs

Lactoferrin suppresses lipopolysaccharide-induced endometritis in mice via down-regulation of the NF-κB pathway. INTERNATIONAL IMMUNOPHARMACOLOGY Int Immunopharmacol. 2015 Sep;28:695 WB Mouse 1:1000 uterine tissues

Reduced expression of citrate synthase leads to excessive superoxide formation and cell apoptosis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2017 Feb 16 WB Human 1:1000 293T cell

Substrate stiffness affects the morphology, proliferation, and radiosensitivity of cervical squamous carcinoma cells. TISSUE & CELL Tissue Cell. 2022 Feb;74:101681 WB，IF Human SiHa cell

FOXD3/FOXD4 is required for the development of hindgut in the rat model of anorectal malformation:. EXPERIMENTAL BIOLOGY AND MEDICINE Exp Biol Med. 2018;243(4):327-333 WB Rat 1:2000 embryos

The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats. MOLECULAR AND CELLULAR BIOCHEMISTRY Mol Cell Biochem. 2015 Jan;399(1):155-165 WB Rat Renal

Is Involved in Fluoride-Induced Human Osteoblast Activation via the Inhibition of Sp1 Binding. BIOLOGICAL TRACE ELEMENT RESEARCH 2018 Jun 21 WB Human 1:3000 osteoblasts

Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Int J Mol Med. 2016 Jul;38(1):148-160 WB Human 1:1000 U937-M1 macrophages

Effect on the dopaminergic metabolism induced by oral exposure to simazine during the prepubertal period in rats. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2017 Oct 20 WB Rat 1:500 midbrain tissues

Olfactory Ensheathing Cell-Conditioned Medium Reverts Aβ 25–35 -Induced Oxidative Damage in SH-SY5Y Cells by Modulating the Mitochondria-Mediated Apoptotic Pathway. CELLULAR AND MOLECULAR NEUROBIOLOGY Cell Mol Neurobiol. 2017 Aug;37(6):1043-1054 WB Human 1:500 SH-SY5Y cell

MicroRNA-429 inhibits the migration and invasion of colon cancer cells by targeting PAK6/cofilin signaling. ONCOLOGY REPORTS 2015 Jun 08 WB Human LOVO cell， SW620 cell

The toxic influence of dibromoacetic acid on the hippocampus and pre-frontal cortex of rat: involvement of neuroinflammation response and oxidative stress. METABOLIC BRAIN DISEASE Metab Brain Dis. 2017 Dec;32(6):2009-2019 WB Rat 1:1000 Pre-frontal cortical,hippocampal tissues

Myocyte-specific enhancer binding factor 2A expression is downregulated during temporal lobe epilepsy. INTERNATIONAL JOURNAL OF NEUROSCIENCE Int J Neurosci. 2016;126(9):786-796 WB Rat 1:1000 brain

Pretreatment with wortmannin alleviates lipopolysaccharide/d-galactosamine-induced acute liver injury. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Biochem Bioph Res Co. 2014 Dec;455:234 WB Mouse 1:1000 Liver

Regulation of intrinsic apoptosis in cycloheximide-treated macrophages by the Sichuan human strain of Chinese Leishmania isolates. ACTA TROPICA Acta Trop. 2016 Jan;153:101 WB Human,Mouse 1:1000 THP-1 macrophages,RAW264.7 macrophages

Felbamate produces antidepressant‐like actions in the chronic unpredictable mild stress and chronic social defeat stress models of depression. FUNDAMENTAL & CLINICAL PHARMACOLOGY 2019 Apr 24 WB Mouse 1:5000 hippocampus

LC3-II may mediate ATR-induced mitophagy in dopaminergic neurons through SQSTM1/p62 pathway. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 2018 Oct 01 WB Rat 1:1000 substantia nigra (SNpc) PC-12 cell

The preparation of a cold-water soluble polysaccharide from Grifola frondosa and its inhibitory effects on MKN-45 cells. GLYCOCONJUGATE JOURNAL 2020 Jun 15 WB Human MKN-45 cell

Inflammatory reaction regulated by microglia plays a role in atrazine-induced dopaminergic neuron degeneration in the substantia nigra. JOURNAL OF TOXICOLOGICAL SCIENCES J Toxicol Sci. 2015 Aug;40(4):437-450 WB Rat 1:500 substantia nigra (SN)

Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood. Brain and Behavior Brain Behav. 2020 Oct;10(10):e01801 WB Rat 1 : 1000 Hippocampal tissue

The tissue expression level of BPI gene in piglets from newborn to weaning and its relationship with Gram-negative bacterial infection. Journal of Integrative Agriculture J Integr Agr. 2020 Dec;19:3065 WB Pig 1:4000 IPEC-J2 cells

Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury. Evidence-based Complementary and Alternative Medicine 2019 Sep 16 WB Rat 1 : 1000 penis tissues

The permeability characteristics and interaction of the main components from Zhizi Bopi decoction in the MDCK cell model. XENOBIOTICA Xenobiotica. 2016;46(8):733-742 WB Dog Madin-Darby canine kidney (MDCK) cell

Effects of Environmental pH on the Growth of Gastric Cancer Cells. Gastroenterology Research and Practice Gastroent Res Pract. 2020;2020:3245359 WB Human SGC-7901 cell, MKN45 cell

miR-301a inhibits adipogenic differentiation of adipose-derived stromal vascular fractions by targeting HOXC8 in sheep. ANIMAL SCIENCE JOURNAL Anim Sci J. 2021 Jan;92(1):e13661 WB Ovine Stromal vascular fractions (SVFs)

Butyrate promotes slow-twitch myofiber formation and mitochondrial biogenesis in finishing pigs via inducing specific microRNAs and PGC-1α expression. JOURNAL OF ANIMAL SCIENCE J Anim Sci. 2019 Jul;97(8):3180-3192 WB Pig 1:3000 longissimus thoracis (LT) muscle

IL-12 induces autophagy in human breast cancer cells through AMPK and the PI3K/Akt pathway. Molecular Medicine Reports Mol Med Rep. 2017 Oct;16(4):4113-4118 WB Human 1:2000 MDA‑MB‑231 cell, MCF‑7 cell

Peroxisome proliferator‑activated receptor‑γ agonist inhibits the mammalian target of rapamycin signaling pathway and has a protective effect in a rat model of status epilepticus. Molecular Medicine Reports Mol Med Rep. 2015 Aug;12(2):1877-1883 WB Rat 1:1000 hippocampal tissues

Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension. CLINICAL AND EXPERIMENTAL HYPERTENSION 2019 Feb 26 WB Rat 1:5000 Lung tissues

Up-regulated cytoplasmic FMRP-interacting protein 1 in intractable temporal lobe epilepsy patients and a rat model. INTERNATIONAL JOURNAL OF NEUROSCIENCE 2015 Aug 24 WB Rat 1:1000 brain

Nickel-Smelting Fumes Increased the Expression of HIF-1α through PI3K/ERK Pathway in NIH/3T3 Cells. JOURNAL OF OCCUPATIONAL HEALTH 2016 Aug 04 WB Rat lung

Effects of Simazine Exposure on Neuronal Development-Related Factors in MN9D Cells. MEDICAL SCIENCE MONITOR Med Sci Monitor. 2016; 22: 2831–2838 WB Mouse 1:500 MN9D cell

Efficacy of phosphocreatine pre-administration on XIAP and Smac in ischemic penumbra of rats with focal cerebral ischemia reperfusion injury. Acta Cirurgica Brasileira 2018 Feb 01 WB Rat brain

Wang, Siqi, et al. "Black TiO2 based nanoprobes for T1-weighted MRI guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells." Biomaterials Science (2018).

Pan, Ming-Ming, et al. "Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats." Food and chemical toxicology 58 (2013): 487-494.

Chen, Rui, et al. "Activation of CD137 Signaling Enhances Vascular Calcification through c-Jun N-Terminal Kinase-Dependent Disruption of Autophagic Flux." Mediators of inflammation 2018 (2018).

The effect of liraglutide on the proliferation, migration, and osteogenic differentiation of human periodontal ligament cells." Journal of periodontal research (2018).

Xie, Changli, et al. "Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function." International journal of molecular medicine 38.1 (2016): 148-160.

Ming, Juan, et al. "Histone Deacetylation in the Promoter of p16 Is Involved in Fluoride-Induced Human Osteoblast Activation via the Inhibition of Sp1 Binding." Biological trace element research (2018): 1-11.

Lu, Xueying, et al. "Luteolin induces apoptosis in vitro through suppressing the MAPK and PI3K signaling pathways in gastric cancer." Oncology letters 14.2 (2017): 1993-2000.

Suo, Guihai, et al. "Abnormal expression of ephrin-A5 affects brain development of congenital hypothyroidism rats." NeuroReport 29.11 (2018): 877-882.

Chen, Qiuyan, et al. "Limb remote ischemic preconditioning protects against cerebral ischemia through down-regulation of aquaporin-4." INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9.7 (2016): 13878-+.

Zhang, Hongru, et al. "Effects of inverse moxibustion on the translocation of telomerase from cardiomyocyte mitochondria of growing mice following exercise." Int J Clin Exp Med 9.6 (2016): 11268-11275.

Dai, Shu-Long, et al. "The expression of hepatic carboxypeptidase E is decreased in patients with cholesterol gallstone." Saudi journal of gastroenterology: official journal of the Saudi Gastroenterology Association 21.4 (2015): 226.

Qian, Fuliang, et al. "MiR‐378a‐3p as a putative biomarker for hepatocellular carcinoma diagnosis and prognosis: Computational screening with experimental validation." Clinical and translational medicine 11.2 (2021): e307.

Zhang, Yong, et al. "Protective effects of Pterostilbene on LPS-induced acute lung injury in mice by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways." Frontiers in pharmacology 11 (2020): 2385.

Wang, Siqi, et al. "Black TiO2 based nanoprobes for T1-weighted MRI guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells." Biomaterials Science (2018).

Qian, Fuliang, et al. "MiR‐378a‐3p as a putative biomarker for hepatocellular carcinoma diagnosis and prognosis: Computational screening with experimental validation." Clinical and translational medicine 11.2 (2021): e307.

Cadmium induces BNIP3-dependent autophagy in chicken spleen by modulating miR-33-AMPK axis. CHEMOSPHERE 2017 Dec 06 WB Chicken 1:1000 Spleen

Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer. ONCOLOGY REPORTS Oncol Rep. 2019 Feb;41(2):989-998 WB Human 1:1000 A549/DPP cell, SKOV3/DDP cell,SGC7901/DDP cell

Facilitating colorectal cancer cell metastasis by targeted binding of long non-coding RNA ENSG00000231881 with miR-133b via VEGFC signaling pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2018 Dec 20 WB Human 1:1000 HCT-116 cell, Lovo cell

Aberrant methylation‐induced dysfunction of p16 is associated with osteoblast activation caused by fluoride. ENVIRONMENTAL TOXICOLOGY Environ Toxicol. 2019 Jan;34(1):37-47 WB Human osteoblasts

Neuroprotective effect of Notch pathway inhibitor DAPT against focal cerebral ischemia/reperfusion 3 hours before model establishment. Neural Regeneration Research Neural Regen Res. 2019 Mar; 14(3): 452–461 WB Mouse 1:4000 Brain tissue

The permeability characteristics and interaction of the main components from Zhizi Bopi decoction in the MDCK cell model. XENOBIOTICA Xenobiotica. 2016;46(8):733-742 WB Dog Madin-Darby canine kidney (MDCK) cell

Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice. Food & Function Food Funct. 2020 Apr;11(4):3167-3179 WB Mouse 1:2000 ileal tissues

Taxifolin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like mouse model via regulating cytoplasmic phospholipase A2 and PPAR-γ pathway. INTERNATIONAL IMMUNOPHARMACOLOGY Int Immunopharmacol. 2021 Oct;99:107900 WB Mouse 1:1000 Skin

Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice. Food & Function Food Funct. 2020 Apr;11(4):3167-3179 WB Mouse 1:2000 ileal tissues

Subcellular Targets of Zinc Oxide Nanoparticles During the Aging Process: Role of Cross-talk Between Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in the Genotoxic Response. TOXICOLOGICAL SCIENCES Toxicol Sci. 2019 Sep;171(1):159-171 WB Human,Hamster AL cell

Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway Frontiers in Endocrinology Rui-Rui Wang WB Mouse

Medium Chain Triglycerides Promote the Uptake of β-Carotene in O/W Emulsions via Intestinal Transporter SR-B1 in Caco-2 Cells JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Yuwei Liu WB Human

Effects of Electroacupuncture on Gastrointestinal Motility Function, Pain, and Inflammation via Transient Receptor Potential Vanilloid 1 in a Rat Model after Colonic Anastomoses DISEASE MARKERS Guonian Wang WB Rat

Gluconeogenesis Alteration and p53-SIRT6-Fox01 Signaling Adaptive Regulation in Sheep from Different Grazing Periods Computational and Mathematical Methods in Medicine Jinling Cao WB Sheep

Voacamine is a novel inhibitor of EGFR exerting oncogenic activity against colorectal cancer through the mitochondrial pathway PHARMACOLOGICAL RESEARCH Sanjun Shi WB Human,Mouse

Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Rui-Fang Sun WB Rat

Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax glabra Roxb herb pair for the treatment of psoriasis PHYTOMEDICINE Ping Li WB Mouse

The natural medicinal fungus Huaier promotes the anti-hepatoma efficacy of sorafenib through the mammalian target of rapamycin-mediated autophagic cell death MEDICAL ONCOLOGY Zhengguang Zhang WB Mouse, Human

Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting

circINSR Inhibits Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions through the miR-152/MEOX2 Axis in Sheep INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Wenzhong Liu WB Sheep ovine stromal vascular fractions (SVFs)

Dietary nucleotides influences intestinal barrier function, immune responses and microbiota in 3-day-old weaned piglets INTERNATIONAL IMMUNOPHARMACOLOGY Yanna Huang WB Pig ileal mucosa

Shikonin potentiates therapeutic efficacy of oxaliplatin through reactive oxygen species-mediated intrinsic apoptosis and endoplasmic reticulum stress in oxaliplatin-resistant colorectal cancer cells DRUG DEVELOPMENT RESEARCH Yajie Zhang WB Human,Mouse HCT116R-xenograft OXA-resistant CRC cells (HCT116R)

Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma Epigenetics Xianhe Xie WB Human Head and neck squamous cell carcinoma (HNSCC)

The pathological significance and potential mechanism of ARHGEF6 in lung adenocarcinoma COMPUTERS IN BIOLOGY AND MEDICINE Shikang Li WB Human A549 cell

Neuropilin-1 promotes mitochondrial structural repair and functional recovery in rats with cerebral ischemia. Nan Liu WB Rat 1:5000 cortex tissue cortical neuron

Guiqi Baizhu prescription ameliorates cytarabine-induced intestinal mucositis by targeting JAK2 to inhibit M1 macrophage polarization. Yong-qi Liu WB Mouse 1:5000 ileal tissue M1 macrophage (M1)

Echinacea Polyphenols Inhibit NLRP3-Dependent Pyroptosis, Apoptosis, and Necroptosis via Suppressing NO Production during Lipopolysaccharide-Induced Acute Lung Injury. Xiaoqiang Liu WB Mouse lung tissue A549 cell

TPT1 promotes the adipogenic differentiation of stromal vascular fractions via the PI3K/AKT pathway and FOXO1 in sheep. Wenzhong Liu WB Sheep stromal vascular fractions (SVFs)

The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer. Wei Kang WB Human 1:5000 AGS cell,MKN1 cell,MKN7 cell,SGC-7901 cell,MGC-803 cell,MKN45 cell,Kato-III cell,NCI-N87 cell,SNU16 cell,MKN28 cell,SNU1 cell

Deciphering the function of Xiangsha-Liujunzi-Tang in enhancing duodenal mucosal barrier by inhibiting MC/Tryptase/PAR-2 signaling pathway in functional dyspepsia rats. Yingxia Cheng WB Rat 1:5000 duodenal tissue

Baicalin suppressed necroptosis and inflammation against chlorpyrifos toxicity; involving in ER stress and oxidative stress in carp gills. Shiwen Xu WB Carp 1:10000 carp gill

Comparison of two kinds of Agrocybe cylindracea polysaccharides: structural characteristic and antitumor activity. An-jun Liu WB Human MGC-803 cell

B7-H3 confers stemness characteristics to gastric cancer cells by promoting glutathione metabolism through AKT/pAKT/Nrf2 pathway. Rui Li WB Human HGC-27 cell,MKN-28 cell

Itaconic acid induces angiogenesis and suppresses apoptosis via Nrf2/autophagy to prolong the survival of multi-territory perforator flaps. Liming Qing WB Rat 1:5000 flap tissue

Machine-learning and combined analysis of single-cell and bulk-RNA sequencing identified a DC gene signature to predict prognosis and immunotherapy response for patients with lung adenocarcinoma. Lai Fancai WB Human 1:1000 lung adenocarcinoma (LUAD) tissue BEAS-2B cell,A549 cell,HCC827 cell,H1975 cell

Dietary antioxidant quercetin overcomes the acquired resistance of Sorafenib in Sorafenib-resistant hepatocellular carcinoma cells through epidermal growth factor receptor signaling inactivation. Zhou Fuqiong WB Mouse，Human 1:2000 Huh7 cell-xenograft Huh7 cell

Aikeqing, a kidney- and spleen-tonifying compound Chinese medicine granule, prevented ovariectomy-induced bone loss in rats via the suppression of osteoclastogenesis. BIOMEDICINE & PHARMACOTHERAPY Xiao-Ling Shen WB Rat，Mouse left femurs bone marrow macrophages (BMMs)

Gastroprotective effect of eupatilin, a polymethoxyflavone from Artemisia argyi H.Lév. & Vaniot, in ethanol-induced gastric mucosal injury via NF-κB signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY Dali Meng WB Mouse，Rat gastric tissues RAW264.7 cell

Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates MIF-induced PASMCs proliferation/migration and vascular remodeling. EUROPEAN JOURNAL OF PHARMACOLOGY Manxiang Li WB Rat 1:5000 lung tissues pulmonary artery smooth muscle cells (PASMCs)

Phosphorylation of RasGRP1 by Shc3 prevents RasGRP1 degradation and contributes to Ras/c-Jun activation in hepatocellular carcinoma. MOLECULAR AND CELLULAR BIOCHEMISTRY Gao Huier WB Human HCCLM3 cell，Huh7 cell,HepG2 cell

GRPR down-regulation inhibits spermatogenesis through Ca2+ mediated by PLCβ/IP3R signaling pathway in long-term formaldehyde-exposed rats. FOOD AND CHEMICAL TOXICOLOGY Dang-xia Zhou WB Rat 1:2000 testicular tissues primary spermatogenic cell

Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells. BIOORGANIC CHEMISTRY Dali Meng WB Human HCT116 cell

Triterpenoids from Meehania fargesii with Cytotoxic Activity1. CHEMISTRY & BIODIVERSITY Dali Meng WB Human HCT116 cell

Apigenin-induced Apoptosis is Reduced via Endoplasmic Reticulum Stress and ATF6/PERK Signaling in Human Gastric Cancer Cells. Pharmacognosy Magazine Liying Hou WB Human SGC-7901 Cell

Fullerol rescues the light-induced retinal damage by modulating Müller glia cell fate. Redox Biology Haiwei Xu WB Mouse,Human 1:1000 eyes MIO-M1 cell

Effects of weaning on intestinal longitudinal muscle-myenteric plexus function in piglets. Science China-Life Sciences Yin Yulong WB Pig 1:5000 Lieum,Colon

ZEA mediates autophagy through the ROS-AMPK-m-TOR pathway to enhance the susceptibility of mastitis induced by Staphylococcus aureus in mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Xiaoyu Hu WB Mouse mammary gland tissues mouse mammary epithelial cells (MMEC)

miR-136 Regulates the Proliferation and Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions by Targeting HSD17B12. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Wenzhong Liu WB Sheep 1:3000 stromal vascular fractions (SVFs)

CADM1 impairs the effect of miR-1246 on promoting cell cycle progression in chemo-resistant leukemia cells. BMC CANCER Linjing Li WB Human 1:2500 Blood K562 cell,HL-60 cell

Microplastics induced inflammation in the spleen of developmental Japanese quail (Coturnix japonica) via ROS-mediated p38 MAPK and TNF signaling pathway activation1 ENVIRONMENTAL POLLUTION Qingyu Zhang WB Bird 1:10000 spleen tissue

Profile of the bile acid FXR-FGF15 pathway in the glucolipid metabolism disorder of diabetic mice suffering from chronic stress PeerJ Weijia Cai WB Mouse 1:1000 liver,ileum

Herbal compound cepharanthine attenuates inflammatory arthritis by blocking macrophage M1 polarization INTERNATIONAL IMMUNOPHARMACOLOGY Chenyang Lu WB Human THP-1 cell

Riboflavin alleviates fluoride-induced ferroptosis by IL-17A-independent system Xc−/GPX4 pathway and iron metabolism in testicular Leydig cells ENVIRONMENTAL POLLUTION Xiang Li WB Mouse 1:5000 TM3 cell

Microparticulated Polygonatum sibiricum polysaccharide shows potent vaccine adjuvant effect INTERNATIONAL JOURNAL OF PHARMACEUTICS Kai Shen WB Mouse 1:1000 bone marrow-derived dendritic cell (BMDC)

Unraveling the immune landscape and therapeutic biomarker PMEPA1 for oxaliplatin resistance in colorectal cancer: A comprehensive approach BIOCHEMICAL PHARMACOLOGY Zhengguang Zhang WB Mouse,Human 1:5000 HCT116R cell-Xenograft HCT116 cell

Interferon-induced transmembrane protein-1 competitively blocks Ephrin receptor A2-mediated Epstein–Barr virus entry into epithelial cells Nature Microbiology Yang Yinggui WB Human 1:5000 NP69 cell,HK1 cell,HEK293 cell

ADPN Regulates Oxidative Stress-Induced Follicular Atresia in Geese by Modulating Granulosa Cell Apoptosis and Autophagy INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Yan Zheng WB Goose 1:8000 follicular tissue

AQP4- and Kir4.1-Mediated Müller Cell Oedema Is Involved in Retinal Injury Induced By Hypobaric Hypoxia MOLECULAR NEUROBIOLOGY Han Cong WB Mouse 1:10000 retinal tissue

Blood–Brain Barrier Permeability is Affected by Changes in Tight Junction Protein Expression at High-Altitude Hypoxic Conditions—this may have Implications for Brain Drug Transport AAPS Journal Liu Guiqin WB Rat 1:2000 brain tissue

Silencing miR-155-5p Alleviates Hippocampal Damage in Kainic Acid-Induced Epileptic Rats via the Dusp14/MAPK Pathway BRAIN RESEARCH BULLETIN Qiong Fang WB Rat 1:5000 hippocampal tissue

Buddleoside-rich Chrysanthemum indicum L. extract modulates macrophage-mediated inflammation to prevent metabolic syndrome induced by unhealthy diet BMC Complementary Medicine and Therapies Zhou Yiqing WB Rat liver tissue

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