• Target：
• HO1

• Fields：
• >>Porphyrin metabolism;>>Metabolic pathways;>>HIF-1 signaling pathway;>>Ferroptosis;>>Mineral absorption;>>Pathways in cancer;>>MicroRNAs in cancer;>>Chemical carcinogenesis - reactive oxygen species;>>Hepatocellular carcinoma;>>Fluid shear stress and atherosclerosis

• Gene Name：
• HMOX1 HO HO1

• Protein Name：
• HO-1

• Human Gene Id：
• 3162

• Human Swiss Prot No：
• P09601

• Mouse Gene Id：
• 15368

• Mouse Swiss Prot No：
• P14901

• Rat Gene Id：
• 24451

• Rat Swiss Prot No：
• P06762

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:2000-1:10000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Heme oxygenase 1 (HO-1) (EC 1.14.99.3)

• Molecular Weight(Da)：
• 33kD

• Observed Band(KD)：
• 33kD

• Background：
• heme oxygenase 1(HMOX1) Homo sapiens Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.,function:Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.,induction:Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.,similarity:Belongs to the heme oxygenase family.,

• Subcellular Location：
• Endoplasmic reticulum membrane

• Expression：
• Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).

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