• Target：
• Ubiquitin

• Fields：
• >>Ubiquitin mediated proteolysis;>>Mitophagy - animal;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis;>>Kaposi sarcoma-associated herpesvirus infection

• Gene Name：
• UBA52/RPS27A/UBB/UBC

• Protein Name：
• Ubiquitin

• Human Gene Id：
• 7311

• Human Swiss Prot No：
• P0CG47/P0CG48/P62979/P62987

• Mouse Gene Id：
• 22187/22190/78294/22186

• Rat Gene Id：
• 192255/50522/100912032/64156

• Rat Swiss Prot No：
• P0CG51/Q63429/P62982/P62986

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-1:1000;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• UBB;Polyubiquitin-B;UBC;Polyubiquitin-C;RPS27A;UBA80;UBCEP1;Ubiquitin-40S ribosomal protein S27a;Ubiquitin carboxyl extension protein 80;UBA52;UBCEP2;Ubiquitin-60S ribosomal protein L40;CEP52;Ubiquitin A-52 residue ribosomal pr

• Molecular Weight(Da)：
• 26kD

• Observed Band(KD)：
• 13-250kD

• Background：
• This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq

• Function：
• function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.,miscellaneous:This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of ubiquitin.,miscellaneous:Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a

• Subcellular Location：
• Cytoplasm

• Expression：
• Brain,Epithelium,Fetal brain cortex,Liver,Lung,Lung adenocarcinoma,Lung cancer,Lymphocyte,P

The RING E3 ligase CLG1 targets GS3 for degradation via the endosome pathway to determine grain size in rice. Molecular Plant Mol Plant. 2021 Oct;14:1699 WB Rice Leaves, flowers

Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development. Cell Death & Disease Cell Death Dis. 2018 Feb;9(3):1-12 WB,IP Human HEK293T cell

Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Scientific Reports Sci Rep-Uk. 2015 Dec;5(1):1-10 WB Mouse jejunum

Studies of proteasome inhibition and apoptosis induction in triple‐negative breast cancer cells by novel amino acid–polypyridine–copper complex. APPLIED ORGANOMETALLIC CHEMISTRY 2019 Jul 22 WB Human 1:1000 MDA-MB-231 cell, CAL-51 cell

Promotion of stem cell-like phenotype of lung adenocarcinoma by FAM83A via stabilization of ErbB2 Cell Death & Disease Yuan Ye WB,Co-IP Human 1:1000 A549 cell,H1299 cell,HEK293 cell

Regenerating Chemotherapeutics through Copper-Based Nanomedicine: Disrupting Protein Homeostasis for Enhanced Tumor Therapy Advanced Healthcare Materials Xubo Wu IF,WB Mouse 4T1 cell

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