• Target：
• Ferritin heavy chain

• Fields：
• >>Ferroptosis;>>Necroptosis;>>Mineral absorption

• Gene Name：
• FTH1

• Protein Name：
• Ferritin heavy chain

• Human Gene Id：
• 2495

• Human Swiss Prot No：
• P02794

• Mouse Gene Id：
• 14319

• Mouse Swiss Prot No：
• P09528

• Rat Gene Id：
• 25319

• Rat Swiss Prot No：
• P19132

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:2000-1:10000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• FTH1;FTH;FTHL6;OK/SW-cl.84;PIG15;Ferritin heavy chain;Ferritin H subunit;Cell proliferation-inducing gene 15 protein

• Molecular Weight(Da)：
• 21kD

• Observed Band(KD)：
• 21kD

• Background：
• This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.,function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis.,function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.,miscellaneous:In human liver the heavy chain is the major chain.,online information:Ferritin entry,similarity:Belongs to the ferritin family.,similarity:Contains 1 ferritin-like diiron domain.,subunit:Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule fo

• Subcellular Location：
• Cytoplasm

• Expression：
• Expressed in the liver.

Dihydroartemisinin Triggers Ferroptosis in Multidrug-Resistant Leukemia Cells WB Human 1:2000 /K562 cell

Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats Frontiers in Molecular Biosciences Sheng Jin WB Rat

FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer’s Disease: Evidence from Single-Cell Transcriptomic Analysis Pharmaceuticals Yu Zheng WB Human

Berberine hydrochloride alleviates imatinib mesylate – induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis Food & Function Jie Zhang WB Rat H9c2 cells

Identification of iron metabolism-related genes as prognostic indicators for papillary thyroid carcinoma: a retrospective study. Minghua Ge WB Human TPC-1 cell

Ginkgolic acid inhibits the expression of SAE1 and induces ferroptosis to exert an anti-hepatic fibrosis effect. PHYTOMEDICINE Bin Jin WB Rat，Human liver HSC-T6 cell,LX-2 cell

STING Mediates LPS-induced Acute Lung Injury by Regulating Ferroptosis EXPERIMENTAL CELL RESEARCH Yanli Gu WB Mouse Lung tissue

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