• Target：
• BMP-2

• Fields：
• >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Pathways in cancer;>>Basal cell carcinoma

• Gene Name：
• BMP2

• Protein Name：
• Bone morphogenetic protein 2

• Human Gene Id：
• 650

• Human Swiss Prot No：
• P12643

• Mouse Gene Id：
• 12156

• Mouse Swiss Prot No：
• P21274

• Rat Gene Id：
• 29373

• Rat Swiss Prot No：
• P49001

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• BMP2;BMP2A;Bone morphogenetic protein 2;BMP-2;Bone morphogenetic protein 2A;BMP-2A

• Molecular Weight(Da)：
• 45kD,13kD

• Observed Band(KD)：
• 30kD,13kD

• Background：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016],

• Function：
• function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.,tissue specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.,

• Subcellular Location：
• Secreted

• Expression：
• Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

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