• Target：
• TFRC

• Gene Name：
• TFRC

• Protein Name：
• Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]

• Human Gene Id：
• 7037

• Human Swiss Prot No：
• P02786

• Mouse Gene Id：
• 22042

• Mouse Swiss Prot No：
• Q62351

• Rat Swiss Prot No：
• Q99376

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-1:1000,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]

• Molecular Weight(Da)：
• 84kD

• Observed Band(KD)：
• 84kD

• Background：
• transferrin receptor(TFRC) Homo sapiens This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],

• Function：
• Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes . Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake . Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway . When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiqu

• Subcellular Location：
• Membrane

Effect of atrazine on accumulation of iron via the iron transport proteins in the midbrain of SD rats. SCIENCE OF THE TOTAL ENVIRONMENT Sci Total Environ. 2021 Aug;780:146666 WB Rat 1:300 Midbrain

Berberine hydrochloride alleviates imatinib mesylate – induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis Food & Function Jie Zhang WB Rat H9c2 cells

IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism Biology Direct Kun Yang IHC Human Colorectal cancer (CRC) tissue

Identification of iron metabolism-related genes as prognostic indicators for papillary thyroid carcinoma: a retrospective study. Minghua Ge WB Human TPC-1 cell

Deferoxamine attenuates visual impairment in retinal ischemia‒reperfusion via inhibiting ferroptosis Scientific Reports Wang Xiaoxuan WB Rat 1:500 retina tissue

Sunitinib induces cardiotoxicity through modulating oxidative stress and Nrf2-dependent ferroptosis in vitro and in vivo CHEMICO-BIOLOGICAL INTERACTIONS Dongjie Li WB Mouse,Rat heart tissue H9c2 cell

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