• Gene Name：
• >>Platinum drug resistance;>>Apoptosis;>>Apoptosis - multiple species;>>Hippo signaling pathway;>>Hepatitis B;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Colorectal cancer

• Protein Name：
• BIRC5

• Sequence：
• Baculoviral IAP repeat-containing protein 5

• Human Gene Id：
• 332

• Human Swiss Prot No：
• O15392

• Mouse Gene Id：
• 11799

• Mouse Swiss Prot No：
• O70201

• Rat Gene Id：
• 64041

• Rat Swiss Prot No：
• Q9JHY7

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• BIRC5;API4;IAP4;Baculoviral IAP repeat-containing protein 5;Apoptosis inhibitor 4;Apoptosis inhibitor survivin

• Molecular Weight(Da)：
• 16kD

• Observed Band(KD)：
• 16kD

• Background：
• This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011],

• Function：
• domain:The BIR repeat is necessary and sufficient for HBXIP binding.,function:May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.,similarity:Belongs to the IAP family.,similarity:Contains 1 BIR repeat.,subcellular location:Localizes on chromosome arms and inner centromeres from prophase through metaphase and t

• Subcellular Location：
• Nucleus

• Expression：
• Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed:16329164). Also expressed in various renal cell carcinoma cell lines (PubMed:10626797). Expressed in cochlea including the organ of Corti, the lateral wall, the interdental cells of the Limbus as well as in Schwann cells and cells of the cochlear nerve and the spiral ganglions (at protein level). Not expressed in cells of the inner and outer sulcus or the Reissner's membrane (at protein level) (PubMed:21364656, PubMed:20627126).

Self-Assembled DNA Nanostructure as a Carrier for Targeted siRNA Delivery in Glioma Cells. International Journal of Nanomedicine Int J Nanomed. 2021; 16: 1805–1817 WB,IF Human 1:150,1:1000 HUVEC cell, U87 cell, U251 cell

Metal-organic frameworks nanoswitch: Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference. Nano Research Nano Res. 2020 Jan;13(1):238-245 WB Human A549 cell

Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2014 Nov 13 WB Human Hep-2 cell

Fang, Zhiqing, et al. "Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway." PloS one 8.5 (2013): e62823.

Zhou, Yanghao, et al. "Self-Assembled DNA Nanostructure as a Carrier for Targeted siRNA Delivery in Glioma Cells." International Journal of Nanomedicine 16 (2021): 1805.

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