• Target：
• FOXP3

• Fields：
• >>Th17 cell differentiation;>>Inflammatory bowel disease

• Gene Name：
• FOXP3

• Protein Name：
• Forkhead box protein P3

• Human Gene Id：
• 50943

• Human Swiss Prot No：
• Q9BZS1

• Mouse Gene Id：
• 20371

• Mouse Swiss Prot No：
• Q99JB6

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-1:1000,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• FOXP3;IPEX;JM2;Forkhead box protein P3;Scurfin

• Molecular Weight(Da)：
• 47kD

• Observed Band(KD)：
• 47kD

• Background：
• The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.,function:Probable transcription factor. Plays a critical role in the control of immune response.,online information:FOXP3 entry,online information:FOXP3 mutation db,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,

• Subcellular Location：
• Nucleus

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Differential Effects of Breed and Nursing on Early-Life Colonic Microbiota and Immune Status as Revealed in a Cross-Fostering Piglet Model. APPLIED AND ENVIRONMENTAL MICROBIOLOGY Appl Environ Microb. 2019 May;: WB Pig 1:100 colonic tissue

Deletion of the C6orf120 gene with unknown function ameliorates autoimmune hepatitis induced by concanavalin A. CELLULAR IMMUNOLOGY Cell Immunol. 2018 Sep;331:9 IHC Rat 1:100 liver

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