• Gene Name：
• >>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>ErbB signaling pathway;>>HIF-1 signaling pathway;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>TGF-beta signaling pathway;>>Apelin signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Thermogenesis;>>Insulin signaling pathway;>>Insulin resistance;>>Shigellosis;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Human immunodeficiency virus 1 infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>Chemical carcinogenesis - receptor activation;>>Colorectal cancer;>>Pancreatic cancer;>>Acute myeloid leukemia;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer;>>Choline metabolism in cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer

• Protein Name：
• RPS6KB1

• Sequence：
• Ribosomal protein S6 kinase beta-1

• Human Gene Id：
• 6198

• Human Swiss Prot No：
• P23443

• Mouse Gene Id：
• 72508

• Mouse Swiss Prot No：
• Q8BSK8

• Rat Gene Id：
• 83840

• Rat Swiss Prot No：
• P67999

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-1:1000,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RPS6KB1;STK14A;Ribosomal protein S6 kinase beta-1;S6K-beta-1;S6K1;70 kDa ribosomal protein S6 kinase 1;P70S6K1;p70-S6K 1;Ribosomal protein S6 kinase I;Serine/threonine-protein kinase 14A;p70 ribosomal S6 kinase alpha;p70 S6 kinas

• Molecular Weight(Da)：
• 75kD

• Observed Band(KD)：
• 70kD

• Background：
• ribosomal protein S6 kinase B1(RPS6KB1) Homo sapiens This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activation by serine/threonine phosphorylation and protein kinase C, inactivated by type 2A phosphatase.,function:Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PPP1R9A/neurabin-1.,tissue specificity:Widely expressed.,

• Subcellular Location：
• Cytoplasm

• Expression：
• Widely expressed.

circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop WB Human 1:1000 /SW620, HCT116 Cells

G-CSF attenuates neuroinflammation and neuronal apoptosis via the mTOR/p70SK6 signaling pathway in neonatal Hypoxia-Ischemia rat model. BRAIN RESEARCH 2020 Apr 01 WB Rat 1:1000 brain

Atheroprotective Pulsatile Flow Induces Ubiquitin-Proteasome–Mediated Degradation of Programmed Cell Death 4 in Endothelial Cells. PLoS One Plos One. 2014 Mar;9(3):e91564 WB Human HUVECs

RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1. Cancer Medicine Cancer Med-Us. 2020 Feb;9(4):1529-1543 WB Human 1:1000 RKO cell, SW480 cell, HCT116 cell,LoVo cell

The role and regulatory mechanism of autophagy in hippocampal nerve cells of piglet damaged by deoxynivalenol. TOXICOLOGY IN VITRO Toxicol In Vitro. 2020 Aug;66:104837 WB Pig 1:1000 piglet hippocampal nerve cells (PHNCs)

Tetrahedral framework nucleic acids inhibit pathological neovascularization and vaso-obliteration in ischaemic retinopathy via PI3K/AKT/mTOR signalling pathway CELL PROLIFERATION Xiaoyan Ding IF Human human umbilical vein endothelial cells (HUVECs)

Nutritional Programming of the Lifespan of Male Drosophila by Activating FOXO on Larval Low-Nutrient Diet Nutrients Mingyao Yang WB Fruit fly body

Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence EXPERIMENTAL GERONTOLOGY Ziqiang Fan WB Mouse 1:1000 NIH-3T3 cell

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