Multiple Myeloma Oncogene 1 (MUM1) mouse mAb(ABT-MUM1)

    • Catalog No.:YM6762
    • Applications:IHC-p
    • Reactivity:Human
      • Gene Name:
      • IRF4 MUM1
      • Protein Name:
      • Multiple Myeloma Oncogene 1 (MUM1)
      • Human Gene Id:
      • 3662
      • Human Swiss Prot No:
      • Q15306
      • Immunogen:
      • Synthesized peptide derived from human Multiple Myeloma Oncogene 1 (MUM1)
      • Specificity:
      • This antibody detects endogenous levels of human Multiple Myeloma Oncogene 1 (MUM1), TRIS-EDTA of pH9.0 was used for Heat-induced epitope retrieval (HIER)
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse
      • Dilution:
      • IHC-p 1:50-500
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)
      • Background:
      • interferon regulatory factor 4(IRF4) Homo sapiens The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],
      • Function:
      • disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.,function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded human Colon. 1, Antibody was diluted at 1:200(4°,overnight). 2, TRIS-EDTA of pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).