ROS1 mouse mAb(ABT-ROS1) Ready to use

  • Catalog No.:YM6701R
  • Applications:IHC-p, WB
  • Reactivity:Human
    • Gene Name:
    • ROS1 MCF3 ROS
    • Protein Name:
    • ROS1
    • Human Gene Id:
    • 6098
    • Human Swiss Prot No:
    • P08922
    • Immunogen:
    • Synthesized peptide derived from human ROS1
    • Specificity:
    • This antibody detects endogenous levels of human ROS1
    • Formulation:
    • Liquid in PBS containing, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse/IgG2a, Kappa
    • Dilution:
    • Ready to use for IHC-p, WB application may demands at least 1:5-20 dilution.
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Storage Stability:
    • 4°C/ 1 years
    • Other Name:
    • Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
    • Background:
    • ROS proto-oncogene 1, receptor tyrosine kinase(ROS1) Homo sapiens This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008],
    • Function:
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.,function:This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 fibronectin type-III domains.,
    • Subcellular Location:
    • Cytoplasmic