Thyroid transcription factor-1 (TTF1) mouse mAb(PT2256) Ready to use

  • Catalog No.:YM6698R
  • Applications:IHC-p
  • Reactivity:Human
  • Description
  • Gene Name:
  • NKX2-1 NKX2A TITF1 TTF1
  • Protein Name:
  • Thyroid transcription factor-1 (TTF1)
  • Human Gene Id:
  • 7080
  • Human Swiss Prot No:
  • P43699
  • Immunogen:
  • Synthesized peptide derived from human Thyroid transcription factor-1 (TTF1)
  • Specificity:
  • This antibody detects endogenous levels of human Thyroid transcription factor-1 (TTF1)
  • Formulation:
  • Liquid in PBS containing, 0.5% BSA and 0.02% sodium azide.
  • Source:
  • Mouse/IgG2b, Kappa
  • Dilution:
  • Ready to use for IHC-p
  • Purification:
  • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Storage Stability:
  • 4°C/ 6 months
  • Other Name:
  • Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1)
  • Background:
  • NKX2-1 (NK2 homeobox 1) encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in NKX2-1 are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for NKX2-1. This gene shares the symbol/alias TTF1 with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
  • Function:
  • negative regulation of transcription from RNA polymerase II promoter, cell morphogenesis, cell morph