pS2(PT2234) mouse mAb

    • Catalog No.:YM6650
    • Applications:IHC-p
    • Reactivity:Human
      • Gene Name:
      • TFF1 BCEI PS2
      • Protein Name:
      • Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2)
      • Human Gene Id:
      • 7031
      • Human Swiss Prot No:
      • P04155
      • Immunogen:
      • Synthesized peptide derived from human pS2
      • Specificity:
      • This antibody detects endogenous levels of human Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2). Heat-induced epitope retrieval (HIER) Cit
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse/IgG2a, Kappa
      • Dilution:
      • IHC-p 1:100-500
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Background:
      • trefoil factor 1(TFF1) Homo sapiens Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008],
      • Function:
      • disease:Expressed in a number of carcinomas including breast (50%), pancreas (70-75%), stomach (50-55%), and large bowel (58%).,function:Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.,similarity:Contains 1 P-type (trefoil) domain.,subunit:Heterodimer with GKN2; disulfide linked.,tissue specificity:Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of
      • Subcellular Location:
      • Cytoplasmic
      • Expression:
      • Colon,Gastric carcinoma,Kidney,Mammary cancer,Stomach,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded human Breast carcinoma. 1,pS2 Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Breast carcinoma. 1,pS2 Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
      • Immunohistochemical analysis of paraffin-embedded human Paget's disease of breast. 1,pS2 Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval