CD74 mouse mAb(PT1667)

    • Catalog No.:YM6613
    • Applications:IHC-p
    • Reactivity:Human
      • Gene Name:
      • CD74 DHLAG
      • Protein Name:
      • CD74
      • Human Gene Id:
      • 972
      • Human Swiss Prot No:
      • P04233
      • Immunogen:
      • Synthesized peptide derived from human CD74
      • Specificity:
      • This antibody detects endogenous levels of human CD74
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse/IgG1, Kappa
      • Dilution:
      • IHC-p 1:100-500
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD antigen CD74)
      • Background:
      • CD74 molecule(CD74) Homo sapiens The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],
      • Function:
      • function:Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Nonamer composed of three alpha/beta/gamma heterotrimers.,
      • Subcellular Location:
      • Cytoplasmic, Membranous
      • Expression:
      • B-cell lymphoma,Liver,Tonsil,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded Tonsil. 1, Antibody was diluted at 1:200(4°,overnight). 2, TRIS-EDTA of pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).