CDX-2 (ABT-CDX2) mouse mAb

    • Catalog No.:YM6305
    • Applications:IHC-p,IF(paraffin section)
    • Reactivity:Human
      • Gene Name:
      • CDX2 CDX3
      • Protein Name:
      • Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2)
      • Human Gene Id:
      • 1045
      • Human Swiss Prot No:
      • Q99626
      • Immunogen:
      • Synthesized peptide derived from human CDX-2
      • Specificity:
      • This antibody detects endogenous levels of human CDX-2. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse/IgG1, Kappa
      • Dilution:
      • IF(paraffin section) 1:50-200 IHC-p 1:20-100
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Background:
      • caudal type homeobox 2(CDX2) Homo sapiens This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012],
      • Function:
      • function:Involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.,PTM:Phosphorylation of Ser-60 mediates the transactivation capacity.,similarity:Belongs to the Caudal homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,
      • Subcellular Location:
      • Nuclear
      • Expression:
      • Colon,Colon carcinoma,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded Colon. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).