CD74 mouse mAb(ABT-CD74)

    • Catalog No.:YM6298
    • Applications:IHC-p
    • Reactivity:Human
    • Description
    • Gene Name:
    • CD74 DHLAG
    • Protein Name:
    • CD74
    • Human Gene Id:
    • 972
    • Human Swiss Prot No:
    • P04233
    • Immunogen:
    • Synthesized peptide derived from human CD74
    • Specificity:
    • This antibody detects endogenous levels of human CD74
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse/IgG1, Kappa
    • Dilution:
    • IHC-p 1:100-500
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD antigen CD74)
    • Background:
    • CD74 molecule encoded by CD74 associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
    • Function:
    • MAPKKK cascade, activation of MAPK activity, prostaglandin biosynthetic process, cell activation, adaptive immune response, immune effector process, leukocyte mediated immunity, lymphocyte mediated immunity, adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains,antigen processing and presentation of exogenous peptide antigen, antigen processing and presentation of peptide antigen via MHC class II, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II,immune system development, leukocyte differentiation, negative regulation of immune system process, positive regulation of immune system process, regulation of leukocyte activation, negative regulation of leukocyte activation,positive regulation of leukocyte activation, protein folding, 'de novo' protein folding, protein complex assembly, 
    • Products Images
    • Immunohistochemical analysis of paraffin-embedded Tonsil. 1, Antibody was diluted at 1:200(4°,overnight). 2, TRIS-EDTA of pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).