Synaptophysin (ABT-SYN) mouse mAb

    • Catalog No.:YM6098
    • Applications:IHC-p
    • Reactivity:Human
    • Description
    • Gene Name:
    • SYP
    • Protein Name:
    • Synaptophysin (Major synaptic vesicle protein p38)
    • Human Gene Id:
    • 6855
    • Human Swiss Prot No:
    • P08247
    • Immunogen:
    • Synthesized peptide derived from human Synaptophysin
    • Specificity:
    • This antibody detects endogenous levels of human Synaptophysin
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse/IgG2a, Kappa
    • Dilution:
    • IHC-p 1:100-500
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Background:
    • synaptophysin(SYP) Homo sapiens This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011],
    • Function:
    • domain:The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.,function:Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.,online information:Synaptophysin entry,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the synaptophysin/synaptobrevin family.,similarity:Contains 1 MARVEL domain.,subunit:Homohexamer or homotetramer.,tissue specificity:Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.,
    • Subcellular Location:
    • Cytoplasmic
    • Expression:
    • Brain,
    • Products Images
    • Immunohistochemical analysis of paraffin-embedded Pancreas. 1, Antibody was diluted at 1:200(4°,overnight). 2, Tris-EDTA,pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
    • Immunohistochemical analysis of paraffin-embedded Pancreas. 1, Antibody was diluted at 1:200(4°,overnight). 2, Tris-EDTA,pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
    • Immunohistochemical analysis of paraffin-embedded Small cell lung carcinoma. 1, Antibody was diluted at 1:200(4°,overnight). 2, Tris-EDTA,pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).