CD206 (PTR2276) mouse mAb
- Catalog No.:YM4678
- Applications:WB; ELISA
- Reactivity:Human; Mouse;
- Target:
- CD206
- Fields:
- >>Phagosome;>>Tuberculosis
- Gene Name:
- MRC1
- Protein Name:
- Macrophage mannose receptor 1
- Human Gene Id:
- 4360
- Human Swiss Prot No:
- P22897
- Mouse Gene Id:
- 17533
- Mouse Swiss Prot No:
- Q61830
- Specificity:
- Synthesized peptide derived from human CD206.AA range:750-850
- Formulation:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source:
- Mouse, Monoclonal/IgG1,kappa
- Dilution:
- WB 1:500-2000, ELISA 1:5000-20000
- Purification:
- Protein G
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- MRC1;CLEC13D;CLEC13DL;MRC1L1;Macrophage mannose receptor 1;MMR;C-type lectin domain family 13 member D;C-type lectin domain family 13 member D-like;Macrophage mannose receptor 1-like protein 1;CD206
- Molecular Weight(Da):
- 166kD
- Observed Band(KD):
- 190kD
- Background:
- The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015],
- Function:
- function:Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,
- Subcellular Location:
- Endosome membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein .
- Expression:
- Milk,Placenta,Testis,
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- Antibody-FAQs
- Products Images
- Various whole cell lysates were separated by 8% SDS-PAGE, and the membrane was blotted with anti-CD206 (PTR2276) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: mouse spleen Lane 2: Hela Predicted band size: 166kDa Observed band size: 190kDa
- Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-SENP2antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: Hela Lane 2: HEK293 Lane 3: MDA-MB-231 Predicted band size: 68kDa Observed band size: 65kDa