Thyroid Peroxidase(TPO) mouse mAb(PT0857)

  • Catalog No.:YM4111
  • Applications:WB
  • Reactivity:Human
    • Gene Name:
    • TPO
    • Protein Name:
    • Thyroid Peroxidase(TPO)
    • Human Gene Id:
    • 7173
    • Human Swiss Prot No:
    • P07202
    • Immunogen:
    • Synthesized peptide derived from human Thyroid Peroxidase(TPO)
    • Specificity:
    • This antibody detects endogenous levels of human Thyroid Peroxidase(TPO)
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse
    • Dilution:
    • WB 1:500-2000
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • Thyroid peroxidase (TPO) (EC 1.11.1.8)
    • Background:
    • thyroid peroxidase(TPO) Homo sapiens This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011],
    • Function:
    • alternative products:Additional isoforms seem to exist,catalytic activity:2 iodide + H(2)O(2) + 2 H(+) = 2 iodine + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.,disease:Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.,function:Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).,online information:Thyroid peroxidase entry,pathway:Hormone b
    • Subcellular Location:
    • extracellular space,mitochondrion,plasma membrane,integral component of plasma membrane,cell surface,integral component of membrane,
    • Expression:
    • Glandular pool- thyroid,Spleen,Thyroid,