Cytokeratin 1 mouse mAb(PT0462)

  • Catalog No.:YM4060
  • Applications:IHC-p,WB
  • Reactivity:Human
    • Gene Name:
    • KRT1 KRTA
    • Protein Name:
    • Cytokeratin 1
    • Human Gene Id:
    • 3848
    • Human Swiss Prot No:
    • P04264
    • Immunogen:
    • Synthesized peptide derived from human Cytokeratin 1
    • Specificity:
    • This antibody detects endogenous levels of human Cytokeratin 1
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse
    • Dilution:
    • IHC-p 1:100-300,WB 1:500-2000
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
    • Background:
    • keratin 1(KRT1) Homo sapiens The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008],
    • Function:
    • disease:Defects in KRT1 are a cause of bullous congenital ichthyosiform erythroderma (BCIE) [MIM:113800]; also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.,disease:Defects in KRT1 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperker
    • Subcellular Location:
    • extracellular space,nucleus,cytoskeleton,plasma membrane,membrane,extracellular matrix,keratin filament,extracellular exosome,blood microparticle,
    • Expression:
    • Epithelium,Fetal brain cortex,Ovarian carcinoma,Platelet,Skin,Tongue,