Histone H3 Monoclonal Antibody, AbFluor 647 Conjugated

  • Catalog No.：YM2086
  • Applications：WB
  • Reactivity：Zebrafish
    • Target：
    • Histone H3
    • Fields：
    • >>Neutrophil extracellular trap formation;>>Alcoholism;>>Shigellosis;>>Transcriptional misregulation in cancer;>>Systemic lupus erythematosus
    • Gene Name：
    • HIST1H3A/HIST1H3B/HIST1H3C/HIST1H3D/HIST1H3E/HIST1H3F/HIST1H3G/HIST1H3H/HIST1H3I/HIST1H3J/HIST2H3A/HIST2H3C/HIST2H3D/H3F3A/H3F3B
    • Protein Name：
    • Histone H3.1/Histone H3.2/Histone H3.3
    • Specificity：
    • Histone H3 Monoclonal Antibody AbFluor™ 647 Conjugated specially designed for your Immunofluorescence analysis.
    • Formulation：
    • Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
    • Source：
    • Monoclonal, Mouse IgG1
    • Purification：
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1mg/ml
    • Storage Stability：
    • Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezi
    • Other Name：
    • HIST1H3A
    • Background：
    • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015],
    • Function：
    • caution:Was originally (PubMed:2587222) thought to originate from mouse.,developmental stage:Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.,function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,miscellaneous:This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).,PTM:Acetylation is generally l
    • Subcellular Location：
    • Nucleus. Chromosome.
    • Expression：
    • Blood,Epithelium,Kidney,Lung,Ovary,Spleen,Uterus,

    Attributes

    • Code：
    • YM2086
    • Size
    • 50μL / 100μL / 500μL
    • Price$：
    • 112 / 192 / 840
    • Delivery：
    • 2024-12-07
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