• Target：
• Egr-1

• Fields：
• >>Apelin signaling pathway;>>GnRH signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>AGE-RAGE signaling pathway in diabetic complications;>>Prion disease;>>Human T-cell leukemia virus 1 infection

• Gene Name：
• EGR1

• Protein Name：
• Early growth response protein 1

• Human Gene Id：
• 1958

• Human Swiss Prot No：
• P18146

• Mouse Swiss Prot No：
• P08046

• Immunogen：
• Purified recombinant fragment of human Egr-1 (aa282-433) expressed in E. Coli.

• Specificity：
• Egr-1 Monoclonal Antibody detects endogenous levels of Egr-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• EGR1;KROX24;ZNF225;Early growth response protein 1;EGR-1;AT225;Nerve growth factor-induced protein A;NGFI-A;Transcription factor ETR103;Transcription factor Zif268;Zinc finger protein 225;Zinc finger protein Krox-24

• Molecular Weight(Da)：
• 78kD

• References：
• 1. J Mol Biol. 2009 Nov 20;394(1):29-45.
  2. Clin Chim Acta. 2010 Jan;411(1-2):67-71.
  3. Gene. 2010 Jan 15;450(1-2):121-7.

• Background：
• The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014],

• Function：
• function:Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.,induction:By growth factors.,similarity:Belongs to the EGR C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,

• Subcellular Location：
• Nucleus . Cytoplasm .

• Expression：
• Detected in neutrophils (at protein level).

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