• Target：
• Dkk-3

• Gene Name：
• DKK3

• Protein Name：
• Dickkopf-related protein 3

• Human Gene Id：
• 27122

• Human Swiss Prot No：
• Q9UBP4

• Mouse Swiss Prot No：
• Q9QUN9

• Immunogen：
• Purified recombinant fragment of human Dkk-3 expressed in E. Coli.

• Specificity：
• Dkk-3 Monoclonal Antibody detects endogenous levels of Dkk-3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DKK3;REIC;Dickkopf-related protein 3;Dickkopf-3;Dkk-3;hDkk-3

• Molecular Weight(Da)：
• 38kD

• References：
• 1. Virchows Arch. 2009 Jun;454(6):639-46.
  2. Gene. 2002 Jan 9;282(1-2):151-8.
  3. J Urol. 2004 Mar;171(3):1314-8.

• Background：
• This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],

• Function：
• function:Inhibitor of Wnt signaling pathway .,PTM:N-glycosylated.,similarity:Belongs to the dickkopf family.,tissue specificity:Highest expression in heart, brain, and spinal cord.,

• Subcellular Location：
• Secreted.

• Expression：
• Highest expression in heart, brain, and spinal cord.

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