CD38-FC recombinant protein
- Catalog No.：YD3064
- Reactivity：Human;
- Purity：
- >90% as determined by SDS-PAGE
- Protein Name：
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2
- Sequence：
- Amino acid:43-300,with FC tag.
- Formulation：
- Phosphate-buffered solution
- Storage Stability：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- Other Name：
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 ;EC 3.2.2.-;EC 3.2.2.6;2'-phospho-ADP-ribosyl cyclase;2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase;EC 2.4.99.20;2'-phospho-cyclic-ADP-ribose transferase;ADP-ribosyl cyclase 1;ADPRC 1;Cyclic ADP-ribose hydrolase 1;cADPR hydrolase 1;T10;CD antigen CD38;CD38;
- Function：
- Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:7961800, PubMed:8253715). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024). Has cADPR hydrolase activity (PubMed:7961800, PubMed:8253715).
- Subcellular Location：
- Cell surface . Membrane ; Single-pass type II membrane protein.
- Expression：
- Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
