• Target：
• Cathepsin L

• Fields：
• >>Autophagy - animal;>>Lysosome;>>Phagosome;>>Apoptosis;>>Antigen processing and presentation;>>Proteoglycans in cancer;>>Rheumatoid arthritis;>>Fluid shear stress and atherosclerosis

• Gene Name：
• CTSL1 CTSL

• Protein Name：
• CATL1 (heavy chain, Cleaved-Ala114)

• Human Gene Id：
• 1514

• Human Swiss Prot No：
• P07711

• Mouse Gene Id：
• 13039

• Mouse Swiss Prot No：
• P06797

• Rat Gene Id：
• 25697

• Rat Swiss Prot No：
• P07154

• Immunogen：
• Synthesized peptide derived from human CATL1 (heavy chain, Cleaved-Ala114)

• Specificity：
• This antibody detects endogenous levels of Human CATL1 (heavy chain, Cleaved-Ala114, protein was cleaved amino acid sequence between 113-114 )

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:1000-2000 ELISA 1:5000-20000

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Cathepsin L1 (EC 3.4.22.15;Major excreted protein;MEP) [Cleaved into: Cathepsin L1 heavy chain;Cathepsin L1 light chain]

• Observed Band(KD)：
• 25 37kD

• Background：
• catalytic activity:Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.,function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Dimer of a heavy and a light chain linked by disulfide bonds.,

• Function：
• proteolysis,

• Subcellular Location：
• Lysosome . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted, extracellular space . Secreted . Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. .; [Isoform 2]: Nucleus . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520). Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520). .

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